Bio Knowledge and Chem Knowledge: Purpose-based Utilization


LSKB (Life Science Knowledge Bank) which can be used for both genomics research and drug discovery research is divided into two categories: Bio Knowledge and Chem Knowledge.
 

Bio Knowledge LSKB primarily accumulates information related to drug target proteins, general biotechnology, DNA microarrays, proteomics, and other information that can be used easily by researchers working in drug discovery. In particular, these databases contain information that allows the user to analyze drug target protein searches from multiple perspectives.
Conversely, Chem Knowledge LSKB systems are enhanced for compound information searches. These systems gather compound data recorded in public databases in advance. Including structural and keyword dictionaries, a Chem Knowledge LSKB contains over 20 million compound data entries and has features that allows compound structure searches and keyword searches. Using these functions, the user can perform many compound searches based on structure or keyword.
Using LSKB in combination with LSKB knowledge annotations offers the user a broad range of possibilities including drug target protein searches, target protein-based ligand searches, or existing drug-based ligand searches.
LSKB: Superior System Operation, Management, and Cost Effectiveness
 

Runs on small-scale PC, not requiring a server configuration for low-level use

Despite containing over 28 million compound structures and related annotations, data created from gene and protein dictionaries and subsequent annotations, disease dictionaries, and more than 20 other data sources, the results of broad-spectrum PubMed searches based on the above dictionary data, and a database containing literature co-occurrence data, LSKB can be operated on a local standard PC server.
If usage is limited to a small number of users, LSKB can be configured easily as an in-house database search system, eliminating the need for an IT specialist to manage server configuration.

High-level database configuration cost performance

LSKB, which is updated three times every year, can significantly reduce costs related to the gathering of public database information and the internal development of a search system. In particular, LSKB demonstrates significantly better cost performance when constructing cumbersome compound structures and annotation databases.

System integration and link with internal corporate databases

To achieve system integration, we have published an Oracle-based database scheme, prepared a Java API, and host the various environments required for web-based integrated operation. This integration helps research organizations realize a significant increase in work efficiency.
The LSKB GateWay provides multiple methods of linking from an internal system to an LSKB hosted on an intranet. It is possible to add original annotations to the annotation database and to merge with an in-house compound database, a level of integration that allows for centralized management of databases.

Powerful security for in-house systems

The keyword, ID, and structural searches are completely internalized and because rules regarding information linked to the internet have been outlined, easily creating a highly secure search system.